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Following oral administration of HYDREAhydroxyurea reaches peak plasma concentrations in 1 to 4 hoursMean peak plasma concentrations and AUCs increase more than proportionally with increase of dose.

Hydroxyurea exerts its anti-cancer effect by preventing synthesis of DNA in the cell by significantly decreasing thyminea nucleotide that is one of the building blocks of DNALack of functional DNA prevents the cancer cell from reproducingwhich results in death of the cellIn this wayhydroxyurea slows or stops the growth of cancer cells in your body.

Hydroxyurea is a human carcinogenIn patients receiving long-term hydroxyurea for myeloproliferative disorderssecondary leukemia has been reportedSkin cancer has also been reported in patients receiving long-term hydroxyureaAdvise protection from sun exposure and monitor for the development of secondary malignancies.

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